Local injection of Lenti-Olig2 at lesion site promotes functional recovery of spinal cord injury in rats
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چکیده
منابع مشابه
Influence of Sexuality in Functional Recovery after Spinal Cord Injury in rats
Background: Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord inj...
متن کاملinfluence of sexuality in functional recovery after spinal cord injury in rats
background: spinal cord injury (sci) is a major clinical condition and research is commonly done to find suitable treatment options. however, there are some degrees of spontaneous recovery after sci and gender is said to be a contributing factor in recovery, but this is controversial. this study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord injur...
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In this study we examined the relationship between autophagy and apoptosis in diabetic rats after spinal cord injury (SCI), also we determined the role of autophagy in diabetes-aggravated neurological injury in vivo and in vitro. Our results showed that diabetes decreased the survival of neurons, promoted astrocytes proliferation, increased inflammatory cells infiltration and inhibited function...
متن کاملExercise Training Promotes Functional Recovery after Spinal Cord Injury
The exercise training is an effective therapy for spinal cord injury which has been applied to clinic. Traditionally, the exercise training has been considered to improve spinal cord function only through enhancement, compensation, and replacement of the remaining function of nerve and muscle. Recently, accumulating evidences indicated that exercise training can improve the function in differen...
متن کاملEcto-domain phosphorylation promotes functional recovery from spinal cord injury
Inhibition of Nogo-66 receptor (NgR) can promote recovery following spinal cord injury. The ecto-domain of NgR can be phosphorylated by protein kinase A (PKA), which blocks activation of the receptor. Here, we found that infusion of PKA plus ATP into the damaged spinal cord can promote recovery of locomotor function. While significant elongation of cortical-spinal axons was not detectable even ...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2017
ISSN: 1755-5930
DOI: 10.1111/cns.12694